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The inhibition of PDE5 in Some tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of NO observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.Sildenafil is close to four,000-fold much more selective for PDE5 as compared to PDE3. PDE3 is includ